[Leu31,Pro34]-Neuropeptide Y(human,rat)

[Leu31,Pro34]-NeuropeptideY(human,rat)名称

中文名：[Leu31,Pro34]-神经肽Y(人类,大鼠)
英文名：(4S)-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxy-propanoyl]amino]-4-oxo-butanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(1S)-2-[[(1S)-2-[(2S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2S)-1-[[(1S)-3-amino-1-[[(1S)-1-[[(1S)-1-[[(1S,2R)-1-[[(1S)-1-[(2S)-2-[[(1S)-1-[[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-3-carboxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoicacid
英文别名：更多

[Leu31,Pro34]-NeuropeptideY(human,rat)生物活性

描述：[Leu31,Pro34]-NeuropeptideY(human,rat)是一种特定的神经肽YY1受体激动剂。[Leu31,Pro34]-NeuropeptideY(human,rat)也抑制Y4,Y5。[Leu31,Pro34]-NeuropeptideY(human,rat)可以增加麻醉大鼠的血压,也增加饮食摄入量。
相关类别：研究领域>>心血管疾病研究领域>>神经疾病信号通路>>G蛋白偶联受体/G蛋白>>神经肽Y受体
靶点：

NPYY1receptor

NPYY5receptor

NPYY4receptor

体外研究：[Leu31,Pro34]-神经肽Y(人,大鼠)对HEK细胞株Y1、Y4、Y5的Ki值分别为0.39nm、0.499nm和0.31nm。[Leu31,Pro34]-神经肽Y(人,大鼠)在HEK细胞系中Y2的Ki>1000[2]。
体内研究：[Leu31,Pro34]-神经肽Y(人,大鼠)(30pmol；微量注射入室旁核)增加大鼠的进食量(350±400g)[3]。
参考文献：

[1].JFuhlendorff,etal.[Leu31,Pro34]neuropeptideY:aspecificY1receptoragonist.ProcNatlAcadSciUSA.1990Jan;87(1):182-6.

[2].KMcCrea,etal.2-36[K4,RYYSA(19-23)]PPanovelY5-receptorpreferringligandwithstrongstimulatoryeffectonfoodintake.RegulPept.2000Feb8;87(1-3):47-58.

[3].AKask,etal.EvidenceforinvolvementofneuropeptideYreceptorsintheregulationoffoodintake:studieswithY1-selectiveantagonistBIBP3226.BrJPharmacol.1998Aug;124(7):1507-15.

[Leu31,Pro34]-NeuropeptideY(human,rat)物理化学性质

分子式：C189H283N54O56S
分子量：4240.67046
储存条件：−20°C

[Leu31,Pro34]-NeuropeptideY(human,rat)安全信息

WGK德国：3

[Leu31,Pro34]-NeuropeptideY(human,rat)英文别名

：(Leu31,Pro34)-NeuropeptideY(human,rat)

[Leu31,Pro34]-Neuropeptide Y(human,rat)重点介绍

【[Leu31,Pro34]-Neuropeptide Y(human,rat)】凯途网[Leu31,Pro34]-Neuropeptide Y(human,rat)CAS号：132699-73-1，[Leu31,Pro34]-Neuropeptide Y(human,rat)MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询[Leu31,Pro34]-Neuropeptide Y(human,rat)。

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[Leu31,Pro34]-NeuropeptideY(human,rat)

[Leu31,Pro34]-Neuropeptide Y(human,rat)