洛贝林

洛贝林名称

中文名：洛贝林
英文名：(-)-lobeline
英文别名：更多

洛贝林生物活性

描述：洛贝林(α-洛贝林；L-洛贝林)是一种亲脂性生物碱,是一种烟碱受体激动剂。洛贝林抑制d-甲基苯丙胺自我给药,无多巴胺毒性。洛贝琳挽救了滥用d-苯丙胺导致的成瘾效应。洛贝林通过抑制DA摄取到突触小泡中并改变突触前DA储存来增加多巴胺(DA)释放[1][2][3]。
相关类别：信号通路>>跨膜转运>>胆碱受体信号通路>>神经信号通路>>胆碱受体信号通路>>神经信号通路>>多巴胺转运蛋白研究领域>>神经疾病
体外研究：洛贝林(0.1-100μM)诱导[3H]天溢出呈非钙依赖性[1]。洛贝琳牌手表抑制[3H]天被突触小体(IC50=80μM)和囊泡(IC50=0.88μM)摄取[1]。洛贝林(0.1-1μM；1小时)抑制1μMd-甲基苯丙胺诱导的纹状体切片释放多巴胺[2]。
体内研究：洛贝林(0.3-3.0mg/kg；皮下注射;单剂量)降低模型大鼠d-去氧麻黄碱的自我给药能力[3]。洛贝林(3mg/kg；皮下注射;7.个周期,共7.次)以非竞争性的方式特别降低大鼠对d-去氧麻黄碱的反应,并增加耐受性发展[3]。动物模型：Sprague-Dawley大鼠(200-250g)[3]剂量：0.3mg/kg、1.0mg/kg和3.0mg/kg用于急性给药；慢性给药3mg/kg给药：皮下注射；测量前15分钟,或每15分钟进行7次；间隔2个干预维持日的d-甲基苯丙胺(0.05mg/kg输注)自我给药结果：d-甲基苯甲酯自我给药减少。
参考文献：

[1].TengL,etal.Lobelineandnicotineevoke[3H]overflowfromratstriatalslicespreloadedwith[3H]dopamine:differentialinhibitionofsynaptosomalandvesicular[3H]dopamineuptake.JPharmacolExpTher.1997Mar;280(3):1432-44.

[2].MillerDK,etal.Lobelineinhibitstheneurochemicalandbehavioraleffectsofamphetamine.JPharmacolExpTher.2001Mar;296(3):1023-34.

[3].HarrodSB,etal.Lobelineattenuatesd-methamphetamineself-administrationinrats.JPharmacolExpTher.2001Jul;298(1):172-9.

洛贝林物理化学性质

密度：1.1±0.1g/cm3
沸点：485.6±15.0°Cat760mmHg
熔点：130-131°
分子式：C22H27NO2
分子量：337.455
闪点：247.5±20.4°C
精确质量：337.204193
PSA：40.54000
LogP：3.61
蒸汽压：0.0±1.3mmHgat25°C
折射率：1.563
储存条件：库房低温通风干燥,与食品原料分开存放

洛贝林MSDS

：DateUpdated:13/FEB/2006
Version1.2
Regulation(EC)No1907/2006
________________________________________________________________________
1-ProductandCompanyInformation
________________________________________________________________________
ProductNameL-LOBELINEFREEBASE
ProductNumberL7149
Company
CenturyBa-ShiBuilding22A-B,
200020Shanghai
TechnicalPhone#86-21-61415566
Fax86-21-61415567
E-mailAddress
________________________________________________________________________
2-HazardsIdentification
________________________________________________________________________
SPECIALINDICATIONOFHAZARDSTOHUMANSANDTHEENVIRONMENT
Toxicbyinhalation,incontactwithskinandifswallowed.
________________________________________________________________________
3-Composition/InformationonIngredients
________________________________________________________________________
ProductNameCAS#ECnoAnnexI
IndexNumber
L-LOBELINEFREEBASE90-69-7202-012-3None
FormulaC22H27NO2
MolecularWeight337,5000AMU
Synonyms8,10-Diphenyllobelionol*
2-(6-(beta-Hydroxy-phenethyl)-1-methyl-2-piperidy
l)acetophenone*
2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperid
inyl)-1-phenylethanone*Inflatine*Lobelin*
(-)-Lobeline*alpha-Lobeline*Lobnico
________________________________________________________________________
4-FirstAidMeasures
________________________________________________________________________
AFTERINHALATION
Ifinhaled,removetofreshair.Ifbreathingbecomesdifficult,
callaphysician.
AFTERSKINCONTACT
Incaseofskincontact,flushwithcopiousamountsofwaterfor
atleast15minutes.Removecontaminatedclothingandshoes.
Callaphysician.
AFTEREYECONTACT
Incaseofcontactwitheyes,flushwithcopiousamountsof
waterforatleast15minutes.Assureadequateflushingby
separatingtheeyelidswithfingers.Callaphysician.
AFTERINGESTION
Ifswallowed,washoutmouthwithwaterprovidedpersonis
conscious.Callaphysician.
________________________________________________________________________
5-FireFightingMeasures
________________________________________________________________________
EXTINGUISHINGMEDIA
Suitable:Carbondioxide,drychemicalpowder,orappropriate
foam.
SPECIALPROTECTIVEEQUIPMENTFORFIREFIGHTERS
Wearself-containedbreathingapparatusandprotectiveclothing
topreventcontactwithskinandeyes.
________________________________________________________________________
6-AccidentalReleaseMeasures
________________________________________________________________________
PROCEDURE(S)OFPERSONALPRECAUTION(S)
Wearrespirator,chemicalsafetygoggles,rubberboots,and
heavyrubbergloves.
METHODSFORCLEANINGUP
Sweepup,placeinabagandholdforwastedisposal.Avoid
raisingdust.Ventilateareaandwashspillsiteaftermaterial
pickupiscomplete.
________________________________________________________________________
7-HandlingandStorage
________________________________________________________________________
________________________________________________________________________
8-ExposureControls/PersonalProtection
________________________________________________________________________
ENGINEERINGCONTROLS
Mechanicalexhaust.
PERSONALPROTECTIVEEQUIPMENT
RespiratoryProtection:Userespiratorsandcomponentstestedand
approvedunderappropriategovernmentstandardssuchasNIOSH(US)
orCEN(EU).Whereriskassessmentshowsair-purifyingrespirators
areappropriateuseafull-faceparticlerespiratortypeN99(US)
ortypeP2(EN143)respiratorcartridgesasabackupto
engineeringcontrols.Iftherespiratoristhesolemeansof
protection,useafull-facesuppliedairrespirator.
HandProtection:Compatiblechemical-resistantgloves.
EyeProtection:Chemicalsafetygoggles.
________________________________________________________________________
9-PhysicalandChemicalProperties
________________________________________________________________________
AppearancePhysicalState:Solid
PropertyValueAtTemperatureorPressure
pHN/A
BP/BPRangeN/A
MP/MPRangeN/A
FlashPointN/A
FlammabilityN/A
AutoignitionTempN/A
OxidizingPropertiesN/A
ExplosivePropertiesN/A
ExplosionLimitsN/A
VaporPressureN/A
PartitionCoefficientN/A
ViscosityN/A
VaporDensityN/A
SaturatedVaporConc.N/A
EvaporationRateN/A
BulkDensityN/A
DecompositionTemp.N/A
SolventContentN/A
WaterContentN/A
SurfaceTensionN/A
ConductivityN/A
MiscellaneousDataN/A
SolubilityN/A
________________________________________________________________________
10-StabilityandReactivity
________________________________________________________________________
STABILITY
Stable:Stable.
HAZARDOUSDECOMPOSITIONPRODUCTS
HazardousDecompositionProducts:Carbonmonoxide,Carbondioxide,
Nitrogenoxides.
HAZARDOUSPOLYMERIZATION
HazardousPolymerization:Willnotoccur
________________________________________________________________________
11-ToxicologicalInformation
________________________________________________________________________
RTECSNUMBER:OJ8480000
ACUTETOXICITY
LD50
Intraperitoneal
Mouse
43500UG/KG
LD50
Intravenous
Mouse
6300UG/KG
LD50
Subcutaneous
Rabbit
35MG/KG
SIGNSANDSYMPTOMSOFEXPOSURE
Stomachpains,vomiting,diarrhea.Exposurecancause:
ROUTEOFEXPOSURE
MultipleRoutes:Harmfulifswallowed,inhaled,orabsorbed
throughskin.Maycauseirritation.
TARGETORGANINFORMATION
Centralnervoussystem.Peripheralnervoussystem.
________________________________________________________________________
12-EcologicalInformation
________________________________________________________________________
Nodataavailable.
________________________________________________________________________
13-DisposalConsiderations
________________________________________________________________________
SUBSTANCEDISPOSAL
Dissolveormixthematerialwithacombustiblesolventandburn
inachemicalincineratorequippedwithanafterburnerand
scrubber.Observeallfederal,state,andlocalenvironmental
regulations.
________________________________________________________________________
14-TransportInformation
________________________________________________________________________
RID/ADR
UN#:1544
Class:6.1
PG:III
ProperShippingName:Alkaloids,solid,n.o.s.
IMDG
UN#:1544
Class:6.1
PG:III
ProperShippingName:Alkaloids,solid,n.o.s.
MarinePollutant:No
SevereMarinePollutant:No
TechnicalName:Required
IATA
UN#:1544
Class:6.1
PG:III
ProperShippingName:Alkaloids,solid,n.o.s.
InhalationPackingGroupI:No
TechnicalName:Required
________________________________________________________________________
15-RegulatoryInformation
________________________________________________________________________
CLASSIFICATIONANDLABELINGACCORDINGTOEUDIRECTIVES
INDICATIONOFDANGER:T
Toxic.
R-PHRASES:23/24/25
Toxicbyinhalation,incontactwithskinandifswallowed.
S-PHRASES:36/37/39-45
Wearsuitableprotectiveclothing,gloves,andeye/face
protection.Incaseofaccidentorifyoufeelunwell,seek
medicaladviceimmediately(showthelabelwherepossible).
COUNTRYSPECIFICINFORMATION
Germany
WGK:3
Self-Classification
________________________________________________________________________
16-OtherInformation
________________________________________________________________________
WARRANTY
Theaboveinformationisbelievedtobecorrectbutdoesnot
purporttobeallinclusiveandshallbeusedonlyasaguide.The
informationinthisdocumentisbasedonthepresentstateofour
knowledgeandisapplicabletotheproductwithregardto
appropriatesafetyprecautions.Itdoesnotrepresentany
shallnotbeheldliableforanydamageresultingfromhandlingor
fromcontactwiththeaboveproduct.Seereversesideofinvoice
orpackingslipforadditionaltermsandconditionsofsale.
unlimitedpapercopiesforinternaluseonly.
DISCLAIMER
ForR&Duseonly.Notfordrug,householdorotheruses.

模块15-法规信息
N/A

模块16-其他信息
N/A

洛贝林毒性和生态

：

洛贝林毒性英文版

洛贝林安全信息

危害码(欧洲)：T
风险声明(欧洲)：23/24/25
安全声明(欧洲)：36/37/39-45
危险品运输编码：UN1544
包装等级：III
危险类别：6.1(b)

洛贝林英文别名

：[2R-[2a,6a(S*)]]-2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone
：2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone
：2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone
：Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-
：lobeline
：Lobron
：Bantron
：Inflatine
：2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone
：Zoolobelin
：Lobelina

洛贝林重点介绍

【洛贝林】凯途网洛贝林CAS号：90-69-7，洛贝林MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询洛贝林。

原料药根据它的来源分为化学合成药和天然化学药两大类。 化学合成药又可分为无机合成药和有机合成药。无机合成药为无机化合物(极个别为元素)，如用于治疗胃及十二指肠溃疡的氢氧化铝、三硅酸镁等；有机合成药主要是由基本有机化工原料，经一系列有机化学反应而制得的药物（如阿司匹林、氯霉素、咖啡因等）

LuoBeiLin

洛貝林